A Prospective Study to Evaluate the Efficacy of Trenexamic Acid in Addition to Oxytocin for Prevention of Post Partum Hemorrhage
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Abstract
Background: One of the most prevalent causes of maternal mortality worldwide is postpartum hemorrhage which can be prevented by early prompt action. Active control of the third stage of labor is one such intervention that is strongly recommended.
Methods: Prospective, randomized, comparative study conducted in Department of Obgyn in MY Hospital, Indore, with comparative groups of 500 each. One group received oxytocin alone and other group received oxytocin and trenexamic acid both.
Results: The mean age in group I was 23.73 ± 3.53 years and in group II it was 23.83 ± 3.34 years, showing a comparable mean age between the two groups. The incidence of anemia was 9.6%, PPH was 6.0% and hemorrhagic shock was 0.6% in group I and in group II it was 8.0, 5.4 and 0.8%, respectively. The incidence of anemia and postpartum hemorrhage was higher in group I in comparison to group II. The mean blood loss in group I was 257.04 ± 139.17 mL, while in group II it was 242.60 ± 120.89 mL, showing a significantly lower blood loss in group II in comparison to the group I shows that trenexamic acid shows decrease and blood loss and anemia and occurance of PPH.
Conclusions: Analysis concluded that tranexamic acid tended to minimize blood loss and the need for blood transfusions during childbirth during caesarean sections and vaginal deliveries and appeared safe and efficient for prevention and control of bleeding during pregnancy.
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REFERENCES
Kumar N. Postpartum Hemorrhage; a Major Killer of Woman: Review
of Current Scenario. Obstet Gynecol Int J 2016;4(4):1-7. DOI:
15406/ogij.2016.04.00116.
Peitsidis P, Kadir RA. Antifibrinolytic therapy with tranexamic acid in
pregnancy and postpartum. Expert Opin Pharmacother. 2011
Mar;12(4):503-16.
WHO recommendation on tranexamic acid for the treatment of
postpartum hemorrhage. Available from:
https://extranet.who.int/rhl/topics/preconception-pregnancychildbirth-
and-postpartum-care/postpartum-care/whorecommendation-
tranexamic-acid-treatment-postpartum-hemorrhage.
Accessed on 29.03.2019.
Sentilhes L, Winer N, Azria E, Sénat MV, Le Ray C, Vardon D, et al.
Tranexamic Acid for the Prevention of Blood Loss after Vaginal
Delivery. N Engl J Med. 2018 Aug 23;379(8):731-42.
Ducloy-Bouthors AS, Jude B, Duhamel A, Broisin F, Huissoud C,
Keita-Meyer H, Mandelbrot L, Tillouche N, Fontaine S, Le Goueff F,
Depret-Mosser S, Vallet B; EXADELI Study Group, Susen S. Highdose
tranexamic acid reduces blood loss in postpartum hemorrhage.
Crit Care. 2011;15(2):R117.
Alavi Z, Atiqpour F, Zare S, Nasiri Z. Effect of tranexamic acid on
postpartum vaginal hemorrhage in Sharieti Hospital of Bandar Abbas in 2014- 2015.
Journal of Research in Medical and Dental Science. 2018;6(3):452-8.
Abdel-Aleem H, Alhusaini TK, Abdel-Aleem MA, Menoufy M,
Gülmezoglu AM. Effectiveness of tranexamic acid on blood loss in
patients undergoing elective cesarean section: randomized clinical trial.
J Matern Fetal Neonatal Med. 2013 Nov;26(17):1705-9.
Saccone G, Della Corte L, D'Alessandro P, Ardino B, Carbone L,
Raffone A, Guida M, Locci M, Zullo F, Berghella V. Prophylactic use
of tranexamic acid after vaginal delivery reduces the risk of primary
postpartum hemorrhage. J Matern Fetal Neonatal Med. 2020
Oct;33(19):3368-76.
Novikova N, Hofmeyr GJ. Tranexamic acid for preventing postpartum
hemorrhage. Cochrane Database Syst Rev. 2010 Jul 7;(7):CD007872.
Peitsidis P, Kadir RA. Antifibrinolytic therapy with tranexamic acid in
pregnancy and postpartum. Expert Opin Pharmacother. 2011
Mar;12(4):503-16.
Sentilhes L, Winer N, Azria E, Senat MV, Ray CL, Vardon D, et al.
Tranexamic acid for the prevention of blood loss after vaginal delivery.
N Engl J Med 2018; 379:731-42.
Corte LD, Saccone G, Locci M, Carbone L, Raffone A, Giampaolino
P, et al. Tranexamic acid for treatment of primary postpartum
hemorrhage after vaginal delivery: a systematic review and meta-analysis
of randomized controlled trials, The Journal of Maternal-Fetal
& Neonatal Medicine. 2020;33(5):869-74.