Prophylactic intrapartum maternal nasal oxygen for better obstetric and neonatal outcomes
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Abstract
Background: Low Apgar scores remain a leading, modifiable contributor to early-neonatal morbidity in low-resource settings. Whether routine intrapartum maternal oxygen benefits normoxic term pregnancies is uncertain. This study assessed the effect of continuous low-flow nasal oxygen on immediate neonatal outcomes.
Methods: In a prospective, quasi-experimental study at a tertiary hospital in central India, 84 women with term singleton pregnancies (37–42 weeks) were alternately allocated to receive either 4–6 L min⁻¹ nasal oxygen throughout active labour (n = 42) or no supplemental oxygen (n = 42). Baseline socio-demographic and obstetric variables were comparable. Primary outcomes were 1- and 5-minute Apgar scores. Secondary outcomes included improvement in fetal-heart-rate (FHR) tracings, mode of delivery and neonatal-intensive-care-unit (NICU) admission. Pearson’s χ² and independent-samples t tests were applied (α = 0.05).
Results: Oxygen significantly reduced low Apgar prevalence. At 1 minute, scores < 7 occurred in 40.5 % versus 66.7 % of controls (χ² = 5.77, p = 0.016); at 5 minutes, 9.5 % versus 35.7 % (χ² = 8.19, p = 0.004). Mean Apgar values were higher in the oxygen group (1 min: 8.83 ± 1.75 vs 7.83 ± 1.71, p = 0.010; 5 min: 9.81 ± 1.23 vs 7.21 ± 1.39, p = 0.041). FHR tracings improved in 71.4 % versus 19.0 % (p = 0.040); caesarean delivery fell to 23.8 % from 52.4 % (p = 0.007); NICU admission declined from 45.2 % to 7.1 % (p< 0.001). No adverse maternal events were observed.
Conclusions: Continuous 4–6 L min⁻¹ intrapartum nasal oxygen markedly improves 1- and 5-minute Apgar scores, stabilises FHR, halves emergency caesareans and cuts NICU admissions in term singleton births. This inexpensive intervention offers a practical bridge when expedited delivery is delayed, supporting its judicious use in similar settings.
Keywords:
Apgar score, Intrapartum Oxygen, Cesarean for fetal distress, Maternal Nasal Oxygen.
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1. Thorngren-Jerneck K. Low 5-minute Apgar score: a population-based register study of 1 million term births. Obstetrics & Gynecology. 2001 Jul;98(1):65–70.
2. Tantu T, Tantu T, Hailu Y, Gashaw D, Melkamu B. Prevalence and factors associated with low 5th minute APGAR score among mothers who birth through emergency cesarean section: prospective cross-sectional study in Ethiopia. BMC Pregnancy Childbirth. 2025 Mar 25;25(1):342.
3. Gudayu TW. Proportion and factors associated with low fifth minute Apgar score among singleton newborn babies in Gondar University referral hospital; North West Ethiopia. Afr H Sci. 2017 May 23;17(1):1.
4. Kumari S, Sharma M, Yadav M, Saraf A, Kabra M, Mehra R. Trends in neonatal outcome with low apgar scores. Indian J Pediatr. 1993 May;60(3):415–22.
5. Hong J, Crawford K, Jarrett K, Triggs T, Kumar S. Five-minute Apgar score and risk of neonatal mortality, severe neurological morbidity and severe non-neurological morbidity in term infants – an Australian population-based cohort study. Lancet Reg Health West Pac. 2024 Jan 13;44:101011.
6. Raina N, Khanna R, Gupta S, Jayathilaka CA, Mehta R, Behera S. Progress in achieving SDG targets for mortality reduction among mothers, newborns, and children in the WHO South-East Asia Region. The Lancet Regional Health - Southeast Asia. 2023 Nov;18:100307.
7. Neonatal mortality [Internet]. UNICEF DATA. [cited 2025 Jun 12]. Available from: https://data.unicef.org/topic/child-survival/neonatal-mortality/
8. India witnesses a steady downward trend in maternal and child mortality towards achievement of SDG 2030 targets [Internet]. [cited 2025 Jun 12]. Available from: https://www.pib.gov.in/www.pib.gov.in/Pressreleaseshare.aspx?PRID=2128024
9. Angolile CM, Max BL, Mushemba J, Mashauri HL. Global increased cesarean section rates and public health implications: A call to action. Health Science Reports. 2023 May;6(5):e1274.
10. Kither H, Monaghan S. Intrauterine fetal resuscitation. Anaesthesia & Intensive Care Medicine. 2016 Jul;17(7):337–40.
11. Hamel MS, Anderson BL, Rouse DJ. Oxygen for intrauterine resuscitation: of unproved benefit and potentially harmful. American Journal of Obstetrics and Gynecology. 2014 Aug;211(2):124–7.
12. Althabe O, Schwarcz RL, Pose SV, Escarcena L, Caldeyro-Barcia R. Effects on fetal heart rate and fetal pO2 of oxygen administration to the mother. American Journal of Obstetrics and Gynecology. 1967 Jul;98(6):858–70.
13. Gare DJ, Shime J, Paul WM, Hoskins M. Oxygen administration during labor. American Journal of Obstetrics and Gynecology. 1969 Nov;105(6):954–61.
14. Thorp JA, Trobough T, Evans R, Hedrick J, Yeast JD. The effect of maternal oxygen administration during the second stage of labor on umbilical cord blood gas values: A randomized controlled prospective trial. American Journal of Obstetrics and Gynecology. 1995 Feb;172(2):465–74.
15. Moors S, Bullens LM, Van Runnard Heimel PJ, Dieleman JP, Kulik W, Bakkeren DL, et al. The effect of intrauterine resuscitation by maternal hyperoxygenation on perinatal and maternal outcome: a randomized controlled trial. American Journal of Obstetrics & Gynecology MFM. 2020 May;2(2):100102.
16. Raghuraman N, Wan L, Temming LA, Woolfolk C, Macones GA, Tuuli MG, et al. Effect of Oxygen vs Room Air on Intrauterine Fetal Resuscitation: A Randomized Noninferiority Clinical Trial. JAMA Pediatr. 2018 Sep 1;172(9):818.
17. Khazin AF, Hon EH, Hehre FW. Effects of maternal hyperoxia on the fetus. American Journal of Obstetrics and Gynecology. 1971 Feb;109(4):628–37.
18. Watkins VY, Martin S, Macones GA, Tuuli MG, Cahill AG, Raghuraman N. The duration of intrapartum supplemental oxygen administration and umbilical cord oxygen content. American Journal of Obstetrics and Gynecology. 2020 Sep;223(3):440.e1-440.e7.
19. ACOG Practice Bulletin No. 106: Intrapartum Fetal Heart Rate Monitoring: Nomenclature, Interpretation, and General Management Principles. Obstetrics & Gynecology. 2009 Jul;114(1):192–202.
20. Ayres‐de‐Campos D, Spong CY, Chandraharan E, FIGO Intrapartum Fetal Monitoring Expert Consensus Panel. FIGO consensus guidelines on intrapartum fetal monitoring: Cardiotocography. Intl J Gynecology & Obste. 2015 Oct;131(1):13–24.
21. Burd J, Quist-Nelson J, Moors S, Raghuraman N, Aly H, Berghella V. Effect of intrapartum oxygen on the rate of cesarean delivery: a meta-analysis. Am J Obstet Gynecol MFM. 2021 Jul;3(4):100374. doi: 10.1016/j.ajogmf.2021.100374. Epub 2021 Apr 6. PMID: 33836306.
22. Burd J, Raghuraman N. Intrapartum Oxygen for Fetal Resuscitation: State of the Science. Curr Obstet Gynecol Rep. 2023 May 18:1-5. doi: 10.1007/s13669-023-00363-w. Epub ahead of print. PMID: 37360259; PMCID: PMC10191681.
23.Wang B, Zeng H, Liu J, Sun M. Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases. Front Neurosci. 2021 Oct 25;15:755554. doi: 10.3389/fnins.2021.755554. PMID: 34759794; PMCID: PMC8573102.