Effects of Lipophagy on Atherosclerosis

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Published: May 15, 2023
DOI: https://doi.org/10.58999/cijmr.v2i01.44
Keywords:
Lipophagy, lipid metabolism, atherosclerosis, foam cell, autophagy

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Manish Juneja
DM(Cardiology), Director, Senior Consultant and Interventional Cardiologist, Rhythm Heart and Critical Care, Nagpur.
https://orcid.org/0000-0002-9039-0553
Pankaj Raut
DM(Cardiology), Director, Senior Consultant and Interventional Cardiologist, Rhythm Heart and Critical Care, Nagpur.
https://orcid.org/0000-0003-0547-5163
Milind Lohkare
MBBS, MD Cardiology, Rhythm Heart and Critical Care , Nagpur
Harshawardhan Ramteke
Anhui Medical University, Hefei, China
Vaishnavi Walke
MBBS (2021), School of International Education, Anhui Medical University, Hefei, China.
https://orcid.org/0000-0002-3119-8676
Sakshi Bhatia
MBBS (2019), School of International Education, Anhui Medical University, Hefei, China.
https://orcid.org/0000-0002-4423-4090

Abstract

An excess build-up of lipids in the arterial wall might result into Atherosclerosis. Lipophagy is the autophagic degradation of lipids that regulates the lipid metabolism in various kinds of cells. Lipophagy replaces intracellular lipid which makes it vital for development and progression of atherosclerosis. This review focuses on advances in lipid metabolism through lipophagy. The role of lipophagy in vascular endothelial cell injury, macrophage lipid accumulation and vascular smooth muscle cells phenotypic shift has been explained by specifying the lipophagy– atherosclerosis relationship.  Novel therapeutic choices can be discovered by understanding the significance of lipophagy in these processes which could be a breakthrough in treatment of atherosclerosis. 

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How to Cite
Juneja , M. ., Raut, P. ., Lohkare, M. ., Ramteke, H., Walke, V., & Bhatia, S. (2023). Effects of Lipophagy on Atherosclerosis. Central India Journal of Medical Research, 2(01), 17–25. https://doi.org/10.58999/cijmr.v2i01.44
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Vol. 2 No. 01 (2023): Central India Journal of Medical Research
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Review Articles
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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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